时间：2025年5月9日（周五）上午10:00
地点：911制品厂麻花豆樱顶老图书馆
主讲人：程亦凡 美国艺术与科学院院士、美国国家科学院院士
题目：冷冻电镜：历史视角与未来挑战
Cryo-EM: its historic perspectives and future challenges
主讲人介绍：
程亦凡，美国艺术与科学院院士、美国国家科学院院士，911制品厂麻花豆杰出校友（2020年）。现任霍华德·休斯医学研究所（Howard Hughes Medical Institute, HHMI）研究员、加州大学旧金山分校（UCSF）生物化学与生物物理学系教授。
程亦凡实验室专注于利用冷冻电镜解析生物大分子结构，尤其是膜蛋白与动态复合物的分子机制。此外，开发冷冻电镜技术以推动结构生物学发展也是其团队的长期研究方向。实验室的里程碑成果包括：开发校正电子束诱导图像运动的算法，以及通过单颗粒冷冻电镜技术首次解析了罢搁笔痴1离子通道的原子级结构等。
程亦凡博士将电子检测相机引入冷冻电镜技术，极大地推动了单粒子冷冻电镜从低分辨率提升至原子结构测定，为该领域带来了突破性的技术变革。发表 150 余篇论文及综述文章，其中在《Nature》《Cell》《Science》等顶尖学术期刊上发表文章40 余篇。曾获国际蛋白质学会颁发的克里斯蒂安·B·安芬森奖（2018年）
Brief Introduction of Professor Yifan Cheng
Dr. Yifan Cheng, a member of the American Academy of Arts and Sciences and the National Academy of Sciences, is a Distinguished Alumnus of Wuhan University (2020). He currently serves as an Investigator at the Howard Hughes Medical Institute (HHMI) and a Professor in the Department of Biochemistry and Biophysics at the University of California San Francisco (UCSF).
The Cheng Laboratory focuses on using cryo-EM to resolve the structures of biological macromolecules, particularly integral membrane proteins and dynamic complexes. A long-standing goal of his team is the development of cryo-EM methodologies to advance structural biology. Landmark achievements include the development of algorithms to correct electron beam-induced image motion and the first atomic-resolution structure determination of the TRPV1 ion channel using single-particle cryo-EM. Throughout his career, Dr. Cheng has made transformative contributions to the field. By introducing electron-detecting cameras into cryo-EM technology, he dramatically advanced single-particle cryo-EM from low-resolution imaging to atomic-level structure determination, sparking a revolutionary breakthrough in the field. He has published over 150 research articles and reviews in leading life science journals, with over 40 appearing in top-tier journals such as Nature, Cell, and Science. He was awarded the Christian B. Anfinsen Award by the Protein Society in 2018.
承办单位：911制品厂麻花豆药学院
邀请人：董长江
